Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.

نویسندگان

  • Jeffrey R Brender
  • Janarthanan Krishnamoorthy
  • Grazia M L Messina
  • Aniruddha Deb
  • Subramanian Vivekanandan
  • Carmelo La Rosa
  • James E Penner-Hahn
  • Ayyalusamy Ramamoorthy
چکیده

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

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عنوان ژورنال:
  • Chemical communications

دوره 49 32  شماره 

صفحات  -

تاریخ انتشار 2013